منابع مشابه
Vitamin B6 biosynthesis in higher plants.
Vitamin B6 is an essential metabolite in all organisms. It can act as a coenzyme for numerous metabolic enzymes and has recently been shown to be a potent antioxidant. Plants and microorganisms have a de novo biosynthetic pathway for vitamin B6, but animals must obtain it from dietary sources. In Escherichia coli, it is known that the vitamin is derived from deoxyxylulose 5-phosphate (an interm...
متن کاملBiosynthesis of vitamin B6 by bacteria.
The biosynthesis and control of vitamin B6 in bacteria could be studied more easily if an organism which produced large amounts of this family of compounds could be found. Unfortunately, the measurements of bacterial vitamin B6 that have been reported have often failed to include the total extracellular vitamin B6, and thus they do not adequately reflect the total vitamin B6 in the whole cultur...
متن کاملPantothenate biosynthesis in higher plants.
Pantothenate (vitamin B5) is a water-soluble vitamin essential for the synthesis of CoA and ACP (acyl-carrier protein, cofactors in energy yielding reactions including carbohydrate metabolism and fatty acid synthesis. Pantothenate is synthesized de novo by plants and micro-organisms; however, animals obtain the vitamin through their diet. Utilizing our knowledge of the pathway in Escherichia co...
متن کاملLysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis.
Substrate channeling has emerged as a common mechanism for enzymatic intermediate transfer. A conspicuous gap in knowledge concerns the use of covalent lysine imines in the transfer of carbonyl-group-containing intermediates, despite their wideuse in enzymatic catalysis. Here we show how imine chemistry operates in the transfer of covalent intermediates in pyridoxal 5'-phosphate biosynthesis by...
متن کاملTetrahydrofolate biosynthesis and distribution in higher plants.
One-carbon transfer reactions are mediated by H4F (tetrahydrofolate), a soluble coenzyme (vitamin B9) that is synthesized de novo by plants and microorganisms, and absorbed from the diet by animals. H4F synthesis in plants is quartered between the plastids, the cytosol and the mitochondria, a spatial distribution that is not observed in the other organisms and that suggests a complex intracellu...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2005
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0506228102